New general synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and benzo[4,5]imidazo[2,1-b]quinazoline derivatives
- 作者: Harutyunyan A.A.1
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隶属关系:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
- 期: 卷 52, 编号 7 (2016)
- 页面: 1012-1017
- 栏目: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/214703
- DOI: https://doi.org/10.1134/S1070428016070150
- ID: 214703
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详细
The reactions of benzene-1,2-diamine with 5-substituted 2-(alkylsulfanyl)-4-methylpyrimidin-6(1H)-ones and 2-(propylsulfanyl)- and 5-iodo-2-(propylsulfanyl)-3,4-dihydroquinazolines at 175–185°C under solvent-free conditions unexpectedly afforded benzo[4,5]imidazo[1,2-a]pyrimidine, benzo[4,5]imidazo[2,1-b]-quinazoline, and 2,2′-(benzene-1,2-diyldiimino)bis[pyrimidin-4(3H)-ones]. The described reaction is the first example of synthesis of these heterocyclic systems by fusion of benzimidazole to pyrimidine or quinazoline and is likely to follow ANRORC mechanism.
作者简介
A. Harutyunyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
编辑信件的主要联系方式.
Email: harutyunyan.arthur@yahoo.com
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
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