Metallomicellar Complex of 1-Hexadecyl-4-aza-1-azoniabicyclo-[2.2.2]octane Bromide with Copper Dibromide for Solubilization of Nitrofurantoin

E. P. Zhil’tsova; M. R. Ibatullina; S. S. Lukashenko; M. P. Kutyreva; L. Ya. Zakharova

doi:10.1134/S1070428018030107

Metallomicellar Complex of 1-Hexadecyl-4-aza-1-azoniabicyclo-[2.2.2]octane Bromide with Copper Dibromide for Solubilization of Nitrofurantoin

Autores: Zhil’tsova E.P.¹, Ibatullina M.R.², Lukashenko S.S.¹, Kutyreva M.P.², Zakharova L.Y.¹
Afiliações:
1. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
2. Kazan (Volga Region) Federal University
Edição: Volume 54, Nº 3 (2018)
Páginas: 431-435
Seção: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/217313
DOI: https://doi.org/10.1134/S1070428018030107
ID: 217313

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Associates of amphiphilic 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide–copper dibromide complex solubilize nitrofurantoin (furadonin). The solubilizing capacity of premicellar aggregates with respect to nitrofurantoin is 15 times higher than that of micelles and is considerably higher (by a factor of 5–16) than the solubilizing effect of micellar solutions of the complex, ligand, and conventional cationic surfactants with respect to Orange OT.