Functionally Substituted Isothiazole- and Isoxazolecarboxamides

Resumo

Convenient synthetic approaches to functionally substituted 5-phenyl-1,2-oxazole-3-carboxamides and 4,5-dichloro-1,2-thiazole-3-carboxamides were developed on the basis of reactions of the corresponding carboxylic acid chlorides with primary aromatic and aliphatic amines. Optimal ratios acid chloride—amine (or amine hydrochloride)–triethylamine were found so that the reaction did not involve active chlorine atom in position 5 of the isothiazole ring.