Enviar artigo por via de e-mail A Convenient Synthesis of N2-Alkylated Guanines
- Autores: Zhu H.T.1, Qin L.Y.1, Liu T.1, Luo Y.1
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Afiliações:
- Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
- Edição: Volume 55, Nº 6 (2019)
- Páginas: 874-878
- Seção: Review
- URL: https://journal-vniispk.ru/1070-4280/article/view/220788
- DOI: https://doi.org/10.1134/S1070428019060198
- ID: 220788
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Resumo
An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.
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Sobre autores
H. Zhu
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
República Popular da China, Shanghai
L. Qin
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
República Popular da China, Shanghai
T. Liu
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
República Popular da China, Shanghai
Y. Luo
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Autor responsável pela correspondência
Email: yluo@chem.ecnu.edu.cn
República Popular da China, Shanghai
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