Enviar artigo por via de e-mail Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone
- Autores: Jassem A.M.1, Raheemah A.H.2, Radhi W.A.3, Alid A.M.4, Jaber H.A.1
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Afiliações:
- Department of Chemistry, College of Education for Pure Sciences
- Department of Chemistry, College of Science
- Department of Chemistry, Polymer Research Center
- Department of Material Science, Polymer Research Center
- Edição: Volume 55, Nº 10 (2019)
- Páginas: 1598-1603
- Seção: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/221304
- DOI: https://doi.org/10.1134/S107042801910021X
- ID: 221304
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Resumo
A four-step procedure has been developed for the synthesis of (S)-3-isopropyl-1-[(R)-1-phenylethyl)- 1,4-diazaspiro[4.5]decan-2-one with high diastereoselectivity (up to 95% de) from (S)-α-aminoisovaleric acid (L-valine). Quantum chemical computations of the synthesized compound have been performed using Gaussian 09 software package.
Sobre autores
A. Jassem
Department of Chemistry, College of Education for Pure Sciences
Autor responsável pela correspondência
Email: ahmedmajeedhsskia@gmail.com
Iraque, Basrah
A. Raheemah
Department of Chemistry, College of Science
Email: ahmedmajeedhsskia@gmail.com
Iraque, Baghdad
W. Radhi
Department of Chemistry, Polymer Research Center
Email: ahmedmajeedhsskia@gmail.com
Iraque, Basrah
A. Alid
Department of Material Science, Polymer Research Center
Email: ahmedmajeedhsskia@gmail.com
Iraque, Basrah
H. Jaber
Department of Chemistry, College of Education for Pure Sciences
Email: ahmedmajeedhsskia@gmail.com
Iraque, Basrah
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