Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone

A. M. Jassem; A. H. Raheemah; W. A. Radhi; A. M. Alid; H. A. Jaber

doi:10.1134/S107042801910021X

Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone

Авторлар: Jassem A.M.¹, Raheemah A.H.², Radhi W.A.³, Alid A.M.⁴, Jaber H.A.¹
Мекемелер:
1. Department of Chemistry, College of Education for Pure Sciences
2. Department of Chemistry, College of Science
3. Department of Chemistry, Polymer Research Center
4. Department of Material Science, Polymer Research Center
Шығарылым: Том 55, № 10 (2019)
Беттер: 1598-1603
Бөлім: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/221304
DOI: https://doi.org/10.1134/S107042801910021X
ID: 221304

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Аннотация

A four-step procedure has been developed for the synthesis of (S)-3-isopropyl-1-[(R)-1-phenylethyl)- 1,4-diazaspiro[4.5]decan-2-one with high diastereoselectivity (up to 95% de) from (S)-α-aminoisovaleric acid (L-valine). Quantum chemical computations of the synthesized compound have been performed using Gaussian 09 software package.