Отправить статью по E-mail Synthesis of 3-(Piperidin-4-yl)-6,7-dihydro-5H-pyrrolo-[2,1-c][1,2,4]triazole and Theoretical Study of the Hydrazone-Hydrazine Tautomerism of the Intermediate Hydrazonation Product
- Авторы: Zhang Q.1, Wan C.1, Ma Y.1, Qin N.1, Ke C.1, Pan Q.2, Zhang X.1
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Учреждения:
- College of Chemistry and Chemical Engineering
- Department of Pharmacy, School of Medicine
- Выпуск: Том 55, № 8 (2019)
- Страницы: 1223-1230
- Раздел: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/221113
- DOI: https://doi.org/10.1134/S1070428019080232
- ID: 221113
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Аннотация
3-(Piperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole was synthesized through a four-step process including etherification, hydrazonation, cyclization, and reduction with an overall yield of 39%. The final product was characterized by 1H NMR and ESI-MS/MS. The molecular structures of benzyl (Z)-4-(2-(pyrrolidin-2-ylidene)hydrazine-1-carbonyl)piperidine-1-carboxylate and related compounds were analyzed using DFT calculations at the B3LYP/6-311+G(d,p) level of theory. The results indicated a higher stability of the hydrazone tautomers.
Об авторах
Q.-Z. Zhang
College of Chemistry and Chemical Engineering
Автор, ответственный за переписку.
Email: qzzhang@xsyu.edu.cn
Китай, Xi’an, 710065
C.-F. Wan
College of Chemistry and Chemical Engineering
Email: xlzhang@xsyu.edu.cn
Китай, Xi’an, 710065
Yu Ma
College of Chemistry and Chemical Engineering
Email: xlzhang@xsyu.edu.cn
Китай, Xi’an, 710065
N.-N. Qin
College of Chemistry and Chemical Engineering
Email: xlzhang@xsyu.edu.cn
Китай, Xi’an, 710065
C.-Y. Ke
College of Chemistry and Chemical Engineering
Email: xlzhang@xsyu.edu.cn
Китай, Xi’an, 710065
Q. Pan
Department of Pharmacy, School of Medicine
Email: xlzhang@xsyu.edu.cn
Китай, Xi’an, 710061
X.-L. Zhang
College of Chemistry and Chemical Engineering
Автор, ответственный за переписку.
Email: xlzhang@xsyu.edu.cn
Китай, Xi’an, 710065
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