Synthesis of 2-Substituted 6-(Polyfluoromethyl)pyrimidine-4-carbaldehyde Acetals


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Heterocyclization of 5,5-difluoro- and 5,5,5-trifluoro-2,4-dioxopentanal dimethyl acetals with amidines in the presence of 4 equiv of triethyl borate afforded 2-substituted 6-(difluoromethyl)- and 6-(trifluoromethyl)pyrimidine-4-carbaldehyde dimethyl acetals in high yields.

作者简介

D. Belyaev

Postovskii Institute of Organic Synthesis, Ural Branch

Email: dlchizhov@ios.uran.ru
俄罗斯联邦, Yekaterinburg

D. Chizhov

Postovskii Institute of Organic Synthesis, Ural Branch

编辑信件的主要联系方式.
Email: dlchizhov@ios.uran.ru
俄罗斯联邦, Yekaterinburg

G. Rusinov

Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University

Email: dlchizhov@ios.uran.ru
俄罗斯联邦, Yekaterinburg; Yekaterinburg

V. Charushin

Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University

Email: dlchizhov@ios.uran.ru
俄罗斯联邦, Yekaterinburg; Yekaterinburg

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