Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure

Resumo

The reaction of 2-methyl-4H-3,1-benzoxazin-4-one and its 6-iodo derivatives with a number of amines in polyphosphoric acid afforded 3- and 3,6-substituted 2-methylquinazolin-4(3H)-ones. The latter reacted with aromatic and heterocyclic aldehydes under solvent-free conditions to give 2-[(E)-2-arylethenyl]-quinazolin-4(3H)-ones. The structure of the synthesized compounds was confirmed by two-dimensional ¹H–¹H NOESY data and X-ray analysis.