Email this article Etiological structure of infectious complications and microbial colonization in patients of COVID-19 hospital of a multidisciplinary federal medical institution
- Authors: Petrova L.V.1,2, Mironov A.Y.2,3, Gusarov V.G.1, Kamyshova D.A.1, Khakulova A.E.1, Zamyatin M.N.1, Suranova T.G.3
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Affiliations:
- National Medical and Surgical Center named after N.I. Pirogov
- Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky
- Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies
- Issue: Vol 26, No 6 (2021)
- Pages: 270-282
- Section: Original study articles
- URL: https://journal-vniispk.ru/1560-9529/article/view/109205
- DOI: https://doi.org/10.17816/EID109205
- ID: 109205
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Abstract
BACKGROUND: Despite the proven importance of secondary bacterial infections influencing the severity of viral respiratory diseases, their etiology is still not well understood. There is a gap in knowledge about the nature, frequency, and antimicrobial resistance profiles of bacterial pathogens in the current COVID-19 pandemic.
AIM: To describe the species spectrum of microorganisms in patients of the COVID-19 Hospital on the basis of a multidisciplinary federal medical institution.
MATERIALS AND METHODS: Clinical samples (blood, lower respiratory tract discharge, urine, other biological materials) from patients with COVID-19 who were treated at the COVID-19 Hospital at a multidisciplinary federal medical institution were obtained and processed.
RESULTS: The bacteriological laboratory received 1821 samples of biomaterial from 452 patients, microorganisms were isolated from 620 (38.0%) samples. Most of the biomaterial was represented by blood — 35.9% and discharge from the lower respiratory tract — 31.7%. The structure of microorganisms was dominated by Candida albicans — 19.7%, Staphylococcus aureus — 10.2%, Klebsiella pneumoniae — 10.1%, Enterococcus faecalis — 7.9%. At the beginning of the period of operation of the Hospital, the most frequently identified microorganisms were S. aureus and Haemophilus influenzae — 19.7% and 7.9%, respectively, while in the final period there was a change in the spectrum of microorganisms to nosocomial ESKAPE -pathogens with multiple drug resistance, the structure was dominated by Acinetobacter baumannii — 24.3%. Antibiotic consumption in the hospital increased from 18.3 DDD/100 patient days in 2019 to 28.8 DDD/100 patient days in 2020.
CONCLUSION: Significant colonization of various loci of patients with COVID-19 by fungi of the genus Candida was revealed. There has been a change in the microbial spectrum of infectious agents from community-acquired (H. influenzae and S. pneumoniae) to nosocomial ESKAPE pathogens with multiple drug resistance. The consumption of antibiotics has increased significantly.
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##article.viewOnOriginalSite##About the authors
Lyudmila V. Petrova
National Medical and Surgical Center named after N.I. Pirogov; Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky
Email: PetrovaLV@pirogov-center.ru
ORCID iD: 0000-0001-6221-9743
SPIN-code: 7042-9620
Russian Federation, Moscow; Moscow
Andrey Yu. Mironov
Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky; Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies
Email: andy.60@mail.ru
ORCID iD: 0000-0002-8544-5230
SPIN-code: 9225-1560
MD, Dr. Sci. (Med.), Professor
Russian Federation, Moscow; MoscowVitaly G. Gusarov
National Medical and Surgical Center named after N.I. Pirogov
Email: gusarovvg@pirogov-center.ru
ORCID iD: 0000-0002-2900-1459
SPIN-code: 9668-5339
MD, Dr. Sci. (Med.), Associate Professor
Russian Federation, MoscowDaria A. Kamyshova
National Medical and Surgical Center named after N.I. Pirogov
Email: d.a.kamyshova@yandex.ru
ORCID iD: 0000-0003-3084-9294
SPIN-code: 1066-2506
Russian Federation, Moscow
Alina E. Khakulova
National Medical and Surgical Center named after N.I. Pirogov
Email: alina.khakulova@mail.ru
ORCID iD: 0000-0003-1257-8937
SPIN-code: 3961-2856
Russian Federation, Moscow
Mikhail N. Zamyatin
National Medical and Surgical Center named after N.I. Pirogov
Author for correspondence.
Email: zamyatinmn@yandex.ru
ORCID iD: 0000-0002-2072-7798
SPIN-code: 5228-8664
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowTatiana G. Suranova
Academy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies
Email: suranovatatiana@mail.ru
ORCID iD: 0000-0003-3411-1027
SPIN-code: 7326-5273
MD, Cand. Sci. (Med.), Associate Professor
Russian Federation, MoscowReferences
- Kannan S, Shaik Syed Ali P, Sheeza A, Hemalatha K. COVID-19 (Novel Coronavirus 2019) — recent trends. Eur Rev Med Pharmacol Sci. 2020;24(4):2006–2011. doi: 10.26355/eurrev_202002_20378
- Sifuentes-Rodríguez E, Palacios-Reyes D. COVID-19: The outbreak caused by a new coronavirus. Bol Med Hosp Infant Mex. 2020;77(2):47–53. doi: 10.24875/BMHIM.20000039
- Sharma B, Sreenivasan P, Biswal M, et al. Bacterial coinfections and secondary infections in COVID-19 patients from a tertiary care hospital of northern India: Time to adhere to culture-based practices. Qatar Med J. 2021;(3):62. doi: 10.5339/qmj.2021.62
- Kuzmenkov AYu, Vinogradova AG, Trushin IV, et al. AMRcloud: a new paradigm in monitoring of antibiotic resistance. Clinical Microbiology and Antimicrobial Chemotherapy. 2019;21(2):119–124. (In Russ). doi: 10.36488/cmac.2019.2.119-124
- Archive of EUCAST tables and documents [Internet]. [cited 2022 Sept 2]. Available from: https://www.eucast.org/ast_of_bacteria/previous_versions_of_documents/.
- Wang Y, Wang Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 2020;92(6):568–576. doi: 10.1002/jmv.25748
- Garcia-Vidal C, Sanjuan G, Moreno-García E, et al.; COVID-19 Researchers Group. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin Microbiol Infect. 2021;27(1):83–88. doi: 10.1016/j.cmi.2020.07.041
- Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009;48(1):1–12. doi: 10.1086/595011
- Yu D, Ininbergs K, Hedman K, et al. Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19. PLoS One. 2020;15(11):e0242533. doi: 10.1371/journal.pone.0242533
- Karpov OE, Gusarov VG, Zamyatin MN, et al. Management of antimicrobial resistance in a hospital: current state and future prospects. Clinical Microbiology and Antimicrobial Chemotherapy. 2020;22(4):277–286. (In Russ). doi: 10.36488/cmac.2020.4.277-286
- Palagin IS, Sukhorukova MV, Dekhnich AV, et al. DARMIS-2018 Study Group. Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter study “DARMIS-2018”. Clinical Microbiology and Antimicrobial Chemotherapy. 2019;21(2):134–146. (In Russ). doi: 10.36488/cmac.2019.2.134-146
- Martinez-Guerra BA, Gonzalez-Lara MF, de-Leon-Cividanes NA, et al. Antimicrobial Resistance Patterns and Antibiotic Use during Hospital Conversion in the COVID-19 Pandemic. Antibiotics (Basel). 2021;10(2):182. doi: 10.3390/antibiotics10020182
- Langford BJ, So M, Raybardhan S, et al. Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis. Clin Microbiol Infect. 2021;27(4):520–531. doi: 10.1016/j.cmi.2020.12.018
- Mirzaei R, Goodarzi P, Asadi M, et al. Bacterial co-infections with SARS-CoV-2. IUBMB Life. 2020;72(10):2097–2111. doi: 10.1002/iub.2356
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