Evaluation of the effectiveness of exosome therapy in patients with androgenetic alopecia: case series
- Authors: Lepekhova A.A.1, Olisova O.Y.1, Smolyannikova V.A.1, Grekova E.V.1, Karray K.1
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Affiliations:
- The First Sechenov Moscow State Medical University (Sechenov University)
- Issue: Vol 28, No 3 (2025)
- Pages: 240-248
- Section: DERMATOLOGY
- URL: https://journal-vniispk.ru/1560-9588/article/view/313071
- DOI: https://doi.org/10.17816/dv646265
- EDN: https://elibrary.ru/ZWHDDH
- ID: 313071
Cite item
Abstract
Androgenetic alopecia is a genetically determined, multifactorial disorder characterized by the miniaturization of terminal hair into pathologically thinned vellus hair, eventually leading to hair loss. Minoxidil and 5α-reductase inhibitors are considered first-line treatments for androgenetic alopecia; however, some patients experience adverse effects or show inadequate response to these therapies, necessitating the development of novel, effective, and safe treatment options.
Exosomes are small membrane-bound vesicles involved in intercellular communication. They can carry proteins, lipids, RNA, and growth factors that may promote prolongation of the anagen phase (growth phase), enhance microcirculation, and stimulate hair follicle regeneration.
This article presents two clinical cases of patients with mild to moderate androgenetic alopecia treated with a solution containing exosomes derived from salmon tissue. Phototrichogram data demonstrated a marked therapeutic benefit in both cases, including increased hair density (via higher anagen hair count) and reduced vellus hair proportion (from 21/12% to 10/8% and from 32/10% to 3/10% before and after treatment, respectively).
Keywords
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##article.viewOnOriginalSite##About the authors
Anfisa A. Lepekhova
The First Sechenov Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: anfisa.lepehova@yandex.ru
ORCID iD: 0000-0002-4365-3090
SPIN-code: 3261-3520
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, MoscowOlga Yu. Olisova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989
MD, Dr. Sci. (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, MoscowVera A. Smolyannikova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: smva@bk.ru
ORCID iD: 0000-0002-7759-5378
SPIN-code: 1953-6595
MD, Dr. Sci. (Medicine), Professor
Russian Federation, MoscowEkaterina V. Grekova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: grekova_kate@mail.ru
ORCID iD: 0000-0002-7968-9829
SPIN-code: 8028-5545
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, MoscowKarim Karray
The First Sechenov Moscow State Medical University (Sechenov University)
Email: karimkarray49@gmail.com
ORCID iD: 0009-0008-1143-7669
MD
Russian Federation, MoscowReferences
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