Polymorphism patterns of oxidative stress biomarker genes in Uzbek patients with acne

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Abstract

BACKGROUND: Inflammatory processes in acne are frequently accompanied by enhanced oxidative stress and reduced antioxidant activity, particularly of the enzyme superoxide dismutase.

AIM: This study aimed to analyze the influence of SOD2 gene polymorphic loci T58C (rs1141718), Ala16Val (rs4880), and C60T (rs11575993) in Uzbek patients with acne of varying severity.

METHODS: A case–control study was conducted using genomic DNA extracted from peripheral blood samples. The study lasted from February to December 2023. A total of 133 patients with acne were examined; the control group included 125 conditionally healthy Uzbek individuals without dermatologic or other diseases.

RESULTS: According to the Global Alliance to Improve Outcomes in Acne severity classification, patients were divided into three groups: mild acne (51; 38.3%), moderate acne (63; 47.4%), and severe acne (19; 14.3%). The unfavorable C allele and the T/C heterozygous genotype of rs1141718 were associated with a markedly increased risk of inflammation driven by oxidative stress; the risk was 8–13 times higher in patients with mild and severe acne (p < 0.05). Moreover, a clear trend toward a higher prevalence of the unfavorable Val allele was observed in the acne group, and the Val allele as well as the homozygous Val/Val genotype were found to be associated with greater clinical disease severity.

CONCLUSION: Polymorphic variants of genes related to oxidative stress biomarkers—particularly SOD2 (T58C, rs1141718; and Ala16Val, rs4880)—play an important role in the pathogenesis of oxidative stress in acne.

About the authors

Nilufar N. Malikova

Center for Development of Professional Qualifications of Medical Workers

Author for correspondence.
Email: dr.malikova@gmail.com
ORCID iD: 0000-0001-6964-8372
SPIN-code: 4972-0478

MD, Cand. Sci. (Medicine), doctoral student

Uzbekistan, Tashkent

Saidkasim S. Arifov

Center for Development of Professional Qualifications of Medical Workers

Email: arifov1961@rambler.ru
ORCID iD: 0000-0001-7207-7283

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Tashkent

Kodirzhon T. Boboev

Republican Specialized Scientific and Practical Medical Center of Hematology

Email: saboboev@mail.ru
ORCID iD: 0000-0002-0297-1447
SPIN-code: 2555-7212

MD, Dr. Sci. (Medicine), Professor

Uzbekistan, Tashkent

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