Email this article THE ROLE OF CD45RA+, CD45RO+ LYMPHOCYTES IN THE PATHOGENESIS OF PSORIASIS
- Authors: Khairutdinov V.R1, Mikhailichenko A.F1, Piskunova A.L2, Mukhina M.S3, Tarasenko G.N4, Samtsov A.V1
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Affiliations:
- ФГОУ ВПО Военно-медицинская академия им. С.М. Кирова
- Северо-Западный государственный медицинский университет им. И.И. Мечникова
- Российский научный центр радиологии и хирургических технологий Росмедтехнологий
- ФГКУ 3-й Центральный военный клинический госпиталь им. А. А. Вишневского Минобороны России
- Issue: Vol 15, No 6 (2012)
- Pages: 30-35
- Section: Articles
- URL: https://journal-vniispk.ru/1560-9588/article/view/36747
- DOI: https://doi.org/10.17816/dv36747
- ID: 36747
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Abstract
Psoriasis is a chronic immunity-dependent dermatosis. The formation of T-cellular immune response, leading to the development of autoimmune inflammation, plays the key role in its pathogenesis. Disorders in immunological memory are essential for psoriasis development. We studied the counts ofCD45RA+, CD45RO+ cell subpopulations and the proliferative activity of skin cells in patients with psoriasis during different periods of the disease. The objects of our research were biopsy specimens collected from 41 psoriasis patients during disease progress, 18 psoriasis patients with remission, and from 16 normal subjects. Immu-nohistochemical study of the skin with anti-CD45RA, anti-CD45RO, anti-Bcl-2, anti-Bcl-6, anti-Ki-67, and anti-CD3ε — Ki-67 antibodies. The counts of CD45RO+ cells in the skin of psoriasis patients during the progressive stage were 3.7 times higher than during remission and 14 times higher than in the skin of normal subjects. High expression of Ki-67 protein in the dermal infiltration cells in psoriatic papules was detected. About 30% dermal proliferating cells ofpsoriasis patients during the progressive stage were T-lymphocytes. The counts of Bcl-2+ and Bcl-6+ cells were many-fold increased in psoriasis patients during the progressive stage and remission in comparison with the counts in normal subjects. These data indicate the involvement of T-cell memory in the pathogenesis of psoriasis and the probable proliferation of T-lymphocytes in the skin of patients during psoriasis exacerbation.
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##article.viewOnOriginalSite##About the authors
V. R Khairutdinov
ФГОУ ВПО Военно-медицинская академия им. С.М. Кирова
Email: haric03@list.ru
канд. мед. наук, ассистент
A. F Mikhailichenko
ФГОУ ВПО Военно-медицинская академия им. С.М. Кирова
Email: dr_nastya@mail.ru
ст. лаборант
A. L Piskunova
Северо-Западный государственный медицинский университет им. И.И. Мечникова
Email: annakmp@mail.ru
аспирант
M. S Mukhina
Российский научный центр радиологии и хирургических технологий Росмедтехнологий
Email: mukhina.mar@yandex.ru
канд. мед. наук, ст. науч. сотр.
G. N Tarasenko
ФГКУ 3-й Центральный военный клинический госпиталь им. А. А. Вишневского Минобороны России
Email: drtarasenko@yandex.ru
канд. мед. наук, доцент
A. V Samtsov
ФГОУ ВПО Военно-медицинская академия им. С.М. Кирова
Email: avsamtsov@mail.ru
д-р мед. наук, проф.
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