电邮这篇文章 Expression of heat shock proteins HSP90 on neutrophils peripheral blood in patients with atopic dermatitis
- 作者: Elistratova I.V1, Morozov S.G.2, Zakharova I.A2
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隶属关系:
- Main Military Clinical Hospital of Internal Troops of the Ministry of Internal Affairs of Russia
- Institute of General Pathology and Pathophysiology
- 期: 卷 19, 编号 3 (2016)
- 页面: 151-154
- 栏目: Articles
- URL: https://journal-vniispk.ru/1560-9588/article/view/37086
- DOI: https://doi.org/10.18821/1560-9588-2016-19-3-151-154
- ID: 37086
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HSP90 expression on the neutrophil plasma membrane has been investigated in patients with atopic dermatitis. Methods. Human peripheral blood cells were stained with monoclonal antibodies to the HSP90 and were analyzed using the flow cytometer. Results. Neutrophils obtained from patients with atopic dermatitis have been found to express the more significant level of HSP90 on plasma membrane, and percentage of these cells has been shown to be higherfor atopic patients compared with healthy donors. Both, neutrophil count and HSP90 fluorescence were increased according elevation of index SCORAD for atopic patients. The most significant elevation in percentage of neutrophils expressing HSP90 on plasma membrane has been found during the first and second weeks of acute phase of the disease. We did not found the significant differences for HSP90 expression on neutrophils dependent on IgE level in the blood serum. Conclusion. HSP90 expression is elevated on the neutrophil plasma membrane from atopic dermatitis patients compared with healthy donors. Percentage of these cells were positive correlated with SCORAD index.
作者简介
I. Elistratova
Main Military Clinical Hospital of Internal Troops of the Ministry of Internal Affairs of RussiaBalashiha, 143915, Russian Federation
Sergey Morozov
Institute of General Pathology and Pathophysiology
Email: biopharm@list.ru
Doctor of Medical Sciences, Professor, Corresponding Member of Russian Academy of Sciences, deputy director for scientific work of Federal State Budgetary Scientific Institution of Institute of General Pathology and Pathophysiology Moscow, 125315, Russian Federation
I. Zakharova
Institute of General Pathology and PathophysiologyMoscow, 125315, Russian Federation
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