Acne, the microbiome and innate immunity


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Abstract

In the laste years several articles focalized on human microbioma - the microorganisms from skin, mucosae, bowel - and on its role in chronic inflammatory diseases of the skin as acne, rosacea, atopic dermatitis, seborrheic dermatitis. In this article the authors present an update on particular acne skin’s microbioma, on innate immunity in acne and new physiopathology mecanisms described in inflammatory process in acne, and at the end we present in vitro, ex vivo and in vivo studies on the microbioma modulation and microbiofilm of pathogenic ribotypes of P. acnes leading to a significant improvement of acne in a series of 74 acne patients.

About the authors

Marius-Anton A Ionescu

University Paris VII

Email: dr.toni.ionescu@gmail.com
MD, PhD, Dermatology Outpatient Clinic University Hospital “Saint-Louis” Paris VII 1, Avenue Claude Vellefaux, 75745 Paris cedex 10, France

M. Feuiolley

Universite de Rouen

Laboratoire de microbiologie, signaux et microenvironnement EA 4312 Франция

J. Enault

Universite de Rouen

Laboratoire de microbiologie, signaux et microenvironnement EA 4312 Франция

P. Wolkenstein

University Paris XII

Dermatology Department, University Hopsital Henry Mondor Creteil

G. Robert

R&D, Laboratoires Dermatologiques d’Uriage

Научно-исследовательское отделение Neuilly-sur-Seine, France

L. Lefeuvre

R&D, Laboratoires Dermatologiques d’Uriage

Научно-исследовательское отделение Neuilly-sur-Seine, France

References

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