Development of compositions and technology of gels containing phytoextracts
- Authors: Kovtun E.V.1, Stepanova E.F.1, Kulshmanova N.N.2, Kulgav Е.А.1, Pleten A.P.3, Prokopov A.A.3, Tatarenko-Kozmina T.Y.4,3
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Affiliations:
- Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia
- FSBEI of HE "Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of Health of Russia
- Moscow State Medical and Dental University named after A.I. Evdokimov of the Ministry of Health of the Russia
- Scientific Research Institute of Clinical Medicine named after Semashko
- Issue: Vol 26, No 12 (2023)
- Pages: 49-54
- Section: Pharmaceutical chemistry
- URL: https://journal-vniispk.ru/1560-9596/article/view/250421
- DOI: https://doi.org/10.29296/25877313-2023-12-06
- ID: 250421
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Abstract
Relevance. Today, interest in the use of natural medicinal substances, medicinal products created on their basis and corresponding dosage forms continues to develop. This interest is associated with the unique properties of various phytocompositions, as well as with the intensive development of such classical sciences as biology, chemistry, and pharmacology. An urgent task is the development and introduction into production of original domestic dosage forms for external use, created on the basis of medicinal plant raw materials, which will solve the issues of successful pharmacotherapy for a number of diseases.
The purpose of our research is to develop optimal compositions of gels based on Ginkgo biloba leaves and Rhodiola rosea rhizomes with roots of thick extracts, their biopharmaceutical studies in vitro for subsequent more in-depth pharmacotechnological studies. Material and methods. The object of our research is soft dosage forms developed on the basis of thick extracts of Ginkgo biloba leaves and Rhodiola rosea rhizomes with roots. Thick extracts were obtained by condensation in a rotary vacuum evaporator), into which the extracts and an alcohol-water-glycerin mixture 1:6:3 were placed. The ratio of thick extract and solvent mixture was 1:1. Mixing was carried out with a stirrer rotating no more than 30 rpm at room temperature until the mass was completely homogenized. The release of biologically active substances was studied by direct diffusion into agar and gelatin gels and by equilibrium dialysis through a semipermeable membrane.
Results. Studies have shown that the most complete and rapid release of the active complex of the thick extract of Rhodiola rosea occurs from the Na-CMC base (TU 9199-001-07508109-2004). The highest degree of release of the active complex of the thick extract of Ginkgo biloba is observed from the chitosan base (TU 9289-067-00472124-03 Bioprogress LLC).
Conclusions. In vitro biopharmaceutical studies were carried out to determine the level of release of the studied active substances of thick extracts of Rhodiola rosea rhizomes with roots and Ginkgo biloba leaves from various gel compositions, allowing to select the optimal composition of the dosage form.
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##article.viewOnOriginalSite##About the authors
E. V. Kovtun
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia
Email: efstapanova@yandex.ru
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical Technology with a course in Medical Biotechnology
Russian Federation, PyatigorskE. F. Stepanova
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia
Author for correspondence.
Email: efstapanova@yandex.ru
Dr.Sc. (Pharm.), Professor, Professor of the Department of Pharmaceutical Technology with a course in Medical Biotechnology
Russian Federation, PyatigorskN. N. Kulshmanova
FSBEI of HE "Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky" of the Ministry of Health of Russia
Email: efstapanova@yandex.ru
Аssistant, Department of Pharmacology and Clinical Pharmacology with a software course
Russian Federation, KrasnoyarskЕ. А. Kulgav
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia
Email: efstapanova@yandex.ru
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical Technology with a course in Medical Biotechnology
Russian Federation, PyatigorskA. P. Pleten
Moscow State Medical and Dental University named after A.I. Evdokimov of the Ministry of Health of the Russia
Email: efstapanova@yandex.ru
Dr.Sc. (Biol.), Professor of the Department of Biological Chemistry
Russian Federation, MoscowA. A. Prokopov
Moscow State Medical and Dental University named after A.I. Evdokimov of the Ministry of Health of the Russia
Email: efstapanova@yandex.ru
Dr.Sc. (Chem.), Associate Professor, Head of Department of General and Bioorganic Chemistry
Russian Federation, MoscowT. Yu. Tatarenko-Kozmina
Scientific Research Institute of Clinical Medicine named after Semashko; Moscow State Medical and Dental University named after A.I. Evdokimov of the Ministry of Health of the Russia
Email: efstapanova@yandex.ru
Dr.Sc. (Biol.), Professor, Head of Department of Medical Biology with the Fundamentals of Cellular and Molecular Biotechnology
Russian Federation, Moscow; MoscowReferences
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