Preparation of the active pharmaceutical substance "Sodium chlorine E6" in the technology of production of drugs for the treatment of malignant neoplasms using a new type of vegetable raw materials
- 作者: Pogartseva Y.A.1, Kauhova I.E.1
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隶属关系:
- Saint-Petersburg State Chemical and Pharmaceutical University
- 期: 卷 27, 编号 9 (2024)
- 页面: 26-31
- 栏目: Pharmaceutical chemistry
- URL: https://journal-vniispk.ru/1560-9596/article/view/264821
- DOI: https://doi.org/10.29296/25877313-2024-09-04
- ID: 264821
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详细
Introduction. Already at the beginning of the twentieth century, it was discovered that a cancer cell is able to accumulate and retain colored substances for a certain time. The raw material for the production of the substance for the above photosensitizer is methylpheophorbide a, which is produced from the biomass of the green microalgae Spirulina Platensis, native to Japan and California. In this regard, there is an urgent question of replacing imported intermediates with more affordable ones. For this purpose, Sosnovsky's hogweed was chosen. Given the presence of cytotoxic properties in hogweed, a promising area of research into the pharmacological properties of extracts from Heraculum Sosnowskyi may be the assessment of their cytostatic activity against tumor cell lines.
The purpose of this study was to obtain and standardize the quality of the active pharmaceutical substance "Sodium chlorine E6" synthesized using a new type of plant raw materials.
Material and methods. Three series of active pharmaceutical substance "Sodium chlorine E6" were obtained from methylpheophorbide a isolated from the dried leaves of borscht Sosnowski (Heracleum Sosnowskyi), prepared in June 2023. The quality indicators of sodium chlorine E6 were determined by the following methods in accordance with the State Pharmacopoeia XIV and XV editions.
The following reagents were used in the synthesis: Acetone C₃H₆O ("HIMMED", Russia), Methanol CH₃OH ("HIMMED", Russia), methylene chlorine CH₂Cl₂ (Scharlau, Spain), Hexane C₆H₁₄ (Sisco Research Laboratories, India), Chloroform CHCl₃ (Sisco Research Laboratories, India), Sodium hydroxide NaOH hç (Pan Reac AppliChem, Spain), Methylpheophorbide A, Hydrochloric acid concentrated HCl (OOO "SIGMA Tek", Russia).
Results. The synthesis of the active pharmaceutical substance "Sodium chlorine E6" from methylpheophorbide a, obtained from the leaves of borscht Sosnowski, was carried out. Standardization of the obtained substance has been carried out. The possibility of using Sosnovsky hogweed as a vegetable raw material for obtaining an intermediate in the production of substances based on E6 chlorine derivatives is evaluated.
Conclusion. In the course of the study, the technology of the active pharmaceutical substance "Sodium chlorine E6" was implemented in the processing of Sosnovsky hogweed. Standardization of the produced substance has been carried out.
作者简介
Yu. Pogartseva
Saint-Petersburg State Chemical and Pharmaceutical University
编辑信件的主要联系方式.
Email: ypogarceva@mail.ru
ORCID iD: 0009-0005-7305-6771
Post-graduate Student
俄罗斯联邦, Professor Popov str. 14A, St. Petersburg, 197376I. Kauhova
Saint-Petersburg State Chemical and Pharmaceutical University
Email: ypogarceva@mail.ru
ORCID iD: 0000-0002-0896-6956
Dr. Sc. (Pharm.), Professor
俄罗斯联邦, Professor Popov str. 14A, St. Petersburg, 197376参考
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