Association of selenium and selenoprotein metab olism characteristics with cartilage damage intensity in patients with rheumatoid, psoriatic, and gouty arthritis
- Авторлар: Skalny A.V.1,2, Korobeynikova T.V.1,2, Menshikova I.V.1, Morozova G.D.1, Sotnikova T.I.1,3, Mak D.V.4, Tinkov A.A.1,5
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Мекемелер:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Peoples Friendship University of Russia
- State Budgetary Healthcare Institution "S.P. Botkin City Clinical Hospital of the Moscow Department Health"
- ANO "Center for Biotic Medicine"
- P.G. Demidov Yaroslavl State University
- Шығарылым: Том 28, № 11 (2025)
- Беттер: 68-76
- Бөлім: Medical chemistry
- URL: https://journal-vniispk.ru/1560-9596/article/view/351549
- DOI: https://doi.org/10.29296/25877313-2025-11-09
- ID: 351549
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Рұқсат берілді
Тек жазылушылар үшін
Аннотация
The objective of the study was to assess the level of selenium (Se) in biosamples, serum selenoprotein P (SELENOP) concentration, and blood glutathione peroxidase (GPX) activity in patients with rheumatoid, psoriatic, and gouty arthritis, as well as to estimate their association with the level of cartilage oligomeric matrix protein (COMP), being a marker of cartilage damage.
Material and Methods. The study enrolled patients with rheumatoid arthritis (RA) (n = 101), psoriatic arthritis (PA) (n = 105), gout (n = 105), and 131 healthy subjects. Assessment of circulating SELENOP and COMP levels was performed using enzyme-linked immunosorbent assay. Blood GPX activity was estimated spectrophotometrically. Analysis of Se levels in blood serum, urine, and hair was performed using inductively-coupled plasma mass-spectrometry.
Results. The obtained data demonstrate that serum COMP levels in patients with inflammatory arthropathies exceeded the control values by a factor of more than 9. SELENOP levels in RA, PA, and gout was 4.9, 3.9, and 2.7–fold lower than in healthy controls, respectively. Serum Se levels in RA and PA patients were 11% and 10% lower compared to the respective control values. Hair and urinary Se levels were less variable. Multiple linear regression analysis showed that serum SELENOP level and urinary Se concentration were significant negative predictors of COMP levels in the examinees even after adjustment for case status.
Conclusion. Therefore, the results of the study showed that patients with inflammatory arthropathies are characterized by lower serum Se and SELENOP levels. Furthermore, SELENOP concentration is characterized by a significant inverse association with cartilage damage intensity, indicative of the modulatory effect of Se on cartilage damage in arthritis.
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##article.viewOnOriginalSite##Авторлар туралы
A. Skalny
I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia
Хат алмасуға жауапты Автор.
Email: skalny3@microelements.ru
ORCID iD: 0000-0001-7838-1366
SPIN-код: 5231-9017
Dr.Sc. (Med.), Professor, Director of the Center for Bioelementology and Human Ecology, Head of the Department of Medical Elementology
Ресей, 8/2 Trubetskaya str. Moscow, 119991; 6 Mikluho-Maklaya str., Moscow, 117198T. Korobeynikova
I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia
Email: tatcvetk@yandex.ru
ORCID iD: 0000-0002-1373-6354
SPIN-код: 7764-6486
Ph.D. (Tech.), Head of the Laboratory of Molecular Dietetics, Associate Professor of the Department of Medical Elementology
Ресей, 8/2 Trubetskaya str. Moscow, 119991; 6 Mikluho-Maklaya str., Moscow, 117198I. Menshikova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: ivmenshikova@mail.ru
ORCID iD: 0000-0003-3181-5272
SPIN-код: 5373-7486
Dr.Sc. (Med.), Professor of the Department of Hospital Therapy No. 1 of the Institute of Clinical Medicine
Ресей, 8/2 Trubetskaya str. Moscow, 119991G. Morozova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: morozova0826@gmail.com
ORCID iD: 0000-0001-8600-902X
SPIN-код: 6174-5932
Laboratory Assistant of the Laboratory of Molecular Dietetics
Ресей, 8/2 Trubetskaya str. Moscow, 119991T. Sotnikova
I.M. Sechenov First Moscow State Medical University (Sechenov University); State Budgetary Healthcare Institution "S.P. Botkin City Clinical Hospital of the Moscow Department Health"
Email: sotnikova_t_i@staff.sechenov.ru
ORCID iD: 0000-0003-4118-4646
SPIN-код: 5424-6395
Ph.D. (Med.), Associate Professor of the Department of Therapy, Rheumatologist
Ресей, 8/2 Trubetskaya str. Moscow, 119991; 5 2ⁿᵈ Botkinsky Proezd, Moscow, 125284D. Mak
ANO "Center for Biotic Medicine"
Email: dariamak25@gmail.com
ORCID iD: 0000-0002-7020-0572
SPIN-код: 8204-4555
Dermatovenerologist
Ресей, 46 Zemlyanoy Val str., Moscow, 105064A. Tinkov
I.M. Sechenov First Moscow State Medical University (Sechenov University); P.G. Demidov Yaroslavl State University
Email: tinkov.a.a@gmail.com
ORCID iD: 0000-0003-0348-6192
SPIN-код: 3329-3442
Dr.Sc. (Med.), Leading Research Scientist of the Laboratory of Molecular Dietetics, Senior Researcher of the Laboratory of Ecobiomonitoring and Quality Control
Ресей, 8/2 Trubetskaya str., Moscow, 119991; 14 Sovetskaya str., Yaroslavl, 150003Әдебиет тізімі
- Fitton J., Melville A. Inflammatory arthropathies. Orthopaedics and Trauma. 2019; 33(4): 204–211.
- Finckh A., Gilbert B., Hodkinson B. et al. Global epidemiology of rheumatoid arthritis. Nature Reviews Rheumatology. 2022; 18(10): 591–602.
- Коротаева Т.В., Корсакова Ю.Л. Псориатический артрит: классификация, клиническая картина, диагностика, лечение. Научно-практическая ревматология. 2018; 56(1): 60–69. [Korotaeva T.V., Korsakova Yu.L. Psoriaticheskij artrit: klassifikaciya, klinicheskaya kartina, diagnostika, lechenie. Nauchno-prakticheskaya revmatologiya. 2018; 56(1): 60–69. (In Russ.)].
- Барскова В.Г. Диагностика подагрического артрита. РМЖ, 2011; 19(10): 614–617. [Barskova V.G. Diagnostika podagricheskogo artrita. RMZh, 2011; 19(10): 614–617. (In Russ.)].
- McKenzie B.J., Haas R., Ferreira G.E. et al. The environmental impact of health care for musculoskeletal conditions: A scoping review. PLoS One. 2022; 17(11): e0276685.
- Bryliński Ł., Brylińska K., Woliński F. et al. Trace Elements—Role in Joint Function and Impact on Joint Diseases. International Journal of Molecular Sciences. 2025; 26(15): 7493.
- Kang D., Lee J., Wu C., Guo X. et al. The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies. Experimental & molecular medicine. 2020; 52(8): 1198–1208.
- Tinkov A.A., Skalny A.V., Guo X. et al. Review of the Protective Effects of Selenium against T-2 Toxin-Induced Toxicity. Chemical Research in Toxicology. 2025; 38(6) 975–996.
- Deng H., Liu H., Yang Z. et al. Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment. Biological Trace Element Research. 2022; 200(10): 4238–4249.
- Ma Y., Zhang X., Fan D. et al. Common trace metals in rheumatoid arthritis: A systematic review and meta-analysis. Journal of Trace Elements in Medicine and Biology. 2019; 56: 81–89.
- Ai P., Lei S., Zhou F. et al. Selenium levels and skin diseases: systematic review and meta-analysis. Journal of Trace Elements in Medicine and Biology. 2020; 62: 126548.
- Wahl L., Chillon T.S., Seemann P. et al. Serum selenium, selenoprotein P and glutathione peroxidase 3 in rheumatoid, psoriatic, juvenile idiopathic arthritis, and osteoarthritis. The Journal of Nutritional Biochemistry. 2025; 135: 109776.
- Smith M.M., Melrose J. COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair. International Journal of Molecular Sciences. 2025; 26(18): 9182.
- Sakthiswary R., Rajalingam S., Hussein H. et al. Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity. Clinical rheumatology. 2017; 36(12): 2683–2688.
- Chandran V., Cook R.J., Edwin J. et al. Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis. Rheumatology. 2010; 49(7): 1399–1405.
- Yu N., Han F., Lin X. et al. The association between serum selenium levels with rheumatoid arthritis. Biological trace element research. 2016; 172(1): 46–52.
- Long M., Xu S., Tie S. et al. Effect of selenium supplementation on inflammatory markers and joint symptoms in patients with rheumatoid arthritis: a meta-analysis and systematic review. Journal of Trace Elements in Medicine and Biology. 2025: 127695.
- Turrubiates-Hernández F.J., Márquez-Sandoval Y.F., González-Estevez G. et al. The relevance of selenium status in rheumatoid arthritis. Nutrients. 2020; 12(10): 3007.
- Ren S.X., Zhang B., Lin Y. et al. Selenium nanoparticles dispersed in phytochemical exert anti-inflammatory activity by modulating catalase, GPx1, and COX-2 gene expression in a rheumatoid arthritis rat model. Medical science monitor: international medical journal of experimental and clinical research. 2019; 25: 991.
- Dębniak T., Baszuk P., Duchnik E. et al. Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease. Biomedicines. 2024; 12(5): 1082.
- Gröber U., Tsiami S., Chillon T.S. et al. Trace Element Deficiency in Axial Spondyloarthritis and Psoriatic Arthritis in Relation to Markers of Inflammation and Remission. International Journal of Molecular Sciences. 2025; 26(10): 4924.
- Toossi P., Sadat Amini S.H., Sadat Amini M.S. et al. Assessment of serum levels of osteopontin, selenium and prolactin in patients with psoriasis compared with healthy controls, and their association with psoriasis severity. Clinical and experimental dermatology. 2015; 40(7): 741–746.
- Ding R.L., Fu C., Zheng Y. et al. The Association Between Psoriasis and Trace Element Serum Levels and Dietary Intake: Results from USA National Health and Nutrition Examination Survey 2011–2014. Clinical, Cosmetic and Investigational Dermatology. 2024; 1449–1458.
- Nazıroğlu M., Yıldız K., Tamtürk B. et al. Selenium and psoriasis. Biological trace element research. 2012; 150(1): 3–9.
- Martí del Moral L., Agil A., Navarro-Alarcón M. et al. Altered serum selenium and uric acid levels and dyslipidemia in hemodialysis patients could be associated with enhanced cardiovascular risk. Biological trace element research. 2011; 144(1): 496–503.
- Siddique M.A., Khan M.A., Bokhari S.A. et al. Ascorbic acid-mediated selenium nanoparticles as potential antihyperuricemic, antioxidant, anticoagulant, and thrombolytic agents. Green Processing and Synthesis. 2024; 13(1): 20230158.
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