Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide

T. N. Shelykh; I. V. Rogachevsky; A. D. Nozdrachev; O. S. Veselkina; S. A. Podzorova; B. V. Krylov; V. B. Plakhova

doi:10.1134/S1607672916010191

Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide

Authors: Shelykh T.N.¹, Rogachevsky I.V.¹, Nozdrachev A.D.¹, Veselkina O.S.¹, Podzorova S.A.¹, Krylov B.V.¹, Plakhova V.B.¹
Affiliations:
1. Pavlov Institute of Physiology
Issue: Vol 466, No 1 (2016)
Pages: 77-80
Section: Biochemistry, Biophysics and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211007
DOI: https://doi.org/10.1134/S1607672916010191
ID: 211007

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Abstract

Using the whole-cell patch-clamp method, the ability of arginine-containing tripeptide Ac-RER-NH₂, dipeptide Ac-RR-NH₂, and free Arg molecule to modulate the membrane excitability of nociceptors was studied. Extracellular Ac-RER-NH₂ upon interaction with the outer membrane of the nociceptive neuron decreases the Z_eff value of the activation gating system of Na_v1.8 channels. Thus, the tripeptide Ac-RER-NH₂ can be considered as a new effective and safe analgesic.