Email this article 1H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients
- Authors: Ublinskiy M.V.1,2, Akhadov T.A.2, Keshishyan R.A.2, Lebedeva I.S.3, Omelchenko M.A.3, Kaleda V.G.3, Varfolomeev S.D.1, Menschikov P.E.1, Semenova N.A.1,2,4
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Affiliations:
- Emanuel Institute of Biochemical Physics
- Research Institute of Emergency Children’s Surgery and Trauma
- Scientific Center of Mental Health
- Semenov Institute of Chemical Physics
- Issue: Vol 468, No 1 (2016)
- Pages: 168-172
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211189
- DOI: https://doi.org/10.1134/S1607672916030029
- ID: 211189
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Abstract
The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the 1H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.
About the authors
M. V. Ublinskiy
Emanuel Institute of Biochemical Physics; Research Institute of Emergency Children’s Surgery and Trauma
Email: peeterem@gmail.com
Russian Federation, ul. Kosygina 4, Moscow, 117977; Bol’shaya Polyanka 22, Moscow, 119180
T. A. Akhadov
Research Institute of Emergency Children’s Surgery and Trauma
Email: peeterem@gmail.com
Russian Federation, Bol’shaya Polyanka 22, Moscow, 119180
R. A. Keshishyan
Research Institute of Emergency Children’s Surgery and Trauma
Email: peeterem@gmail.com
Russian Federation, Bol’shaya Polyanka 22, Moscow, 119180
I. S. Lebedeva
Scientific Center of Mental Health
Email: peeterem@gmail.com
Russian Federation, Moscow
M. A. Omelchenko
Scientific Center of Mental Health
Email: peeterem@gmail.com
Russian Federation, Moscow
V. G. Kaleda
Scientific Center of Mental Health
Email: peeterem@gmail.com
Russian Federation, Moscow
S. D. Varfolomeev
Emanuel Institute of Biochemical Physics
Email: peeterem@gmail.com
Russian Federation, ul. Kosygina 4, Moscow, 117977
P. E. Menschikov
Emanuel Institute of Biochemical Physics
Author for correspondence.
Email: peeterem@gmail.com
Russian Federation, ul. Kosygina 4, Moscow, 117977
N. A. Semenova
Emanuel Institute of Biochemical Physics; Research Institute of Emergency Children’s Surgery and Trauma; Semenov Institute of Chemical Physics
Email: peeterem@gmail.com
Russian Federation, ul. Kosygina 4, Moscow, 117977; Bol’shaya Polyanka 22, Moscow, 119180; ul. Kosygina 4, Moscow, 119991
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