The role of electrostatic interactions in the process of diffusional encounter and docking of electron transport proteins

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Abstract

Electrostatic interaction of plastocyanin and cytochrome f in the process of protein–protein complex formation was investigated by computer simulation methods. It was shown that long-range electrostatic interaction promotes energetically favorable mutual orientation of protein molecules at distances between their cofactors shorter than 5 nm. At distances shorter than 3 nm, these electrostatic interactions lead to a significantly detectable increase in the rate of convergence of the cofactors.

About the authors

I. B. Kovalenko

Biological Faculty

Author for correspondence.
Email: ikovalenko78@gmail.com
Russian Federation, Moscow, 119991

S. S. Khrushchev

Biological Faculty

Email: ikovalenko78@gmail.com
Russian Federation, Moscow, 119991

V. A. Fedorov

Biological Faculty

Email: ikovalenko78@gmail.com
Russian Federation, Moscow, 119991

G. Yu. Riznichenko

Biological Faculty

Email: ikovalenko78@gmail.com
Russian Federation, Moscow, 119991

A. B. Rubin

Biological Faculty

Email: ikovalenko78@gmail.com
Russian Federation, Moscow, 119991

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