Email this article Involvement of transcription factor Oct-1 in the regulation of JAK–STAT signaling pathway in cells of Burkitt lymphoma
- Authors: Pankratova E.V.1, Stepchenko A.G.1, Krylova I.D.2, Portseva T.N.1, Georgieva S.G.1
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Affiliations:
- Engelhardt Institute of Molecular Biology
- Moscow State Pedagogical University
- Issue: Vol 468, No 1 (2016)
- Pages: 229-231
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211337
- DOI: https://doi.org/10.1134/S1607672916030200
- ID: 211337
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Abstract
We studied the role of transcription factor Oct-1 in the regulation of expression of genes of the JAK–STAT signaling pathway in the Namalwa Burkitt’s lymphoma cell line. Overexpression of Oct-1 isoforms (Oct-1A, Oct-1L, and Oct-1X) causes a decrease in the activity of four genes involved in the JAK–STAT signaling pathway—IFNAR2, STAT1, STAT2, and STAT4. As a result of our research, it was found that genes STAT2 and STAT4 are direct targets for Oct-1 protein.
About the authors
E. V. Pankratova
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
A. G. Stepchenko
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
I. D. Krylova
Moscow State Pedagogical University
Email: tanjnij86@mail.ru
Russian Federation, ul. Malaya Pirogovskaya 1, Moscow, 119992
T. N. Portseva
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
S. G. Georgieva
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
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