Email this article Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide
- Authors: Yurinskaya M.M.1,2, Funikov S.Y.2, Evgen’ev M.B.1,2, Vinokurov M.G.1
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Affiliations:
- Institute of Cell Biophysics
- Engelhardt Institute of Molecular Biology
- Issue: Vol 469, No 1 (2016)
- Pages: 239-243
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211371
- DOI: https://doi.org/10.1134/S1607672916040025
- ID: 211371
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Abstract
The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.
About the authors
M. M. Yurinskaya
Institute of Cell Biophysics; Engelhardt Institute of Molecular Biology
Email: mg-vinokurov@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Vavilova 32, Moscow, 119991
S. Y. Funikov
Engelhardt Institute of Molecular Biology
Email: mg-vinokurov@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
M. B. Evgen’ev
Institute of Cell Biophysics; Engelhardt Institute of Molecular Biology
Email: mg-vinokurov@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Vavilova 32, Moscow, 119991
M. G. Vinokurov
Institute of Cell Biophysics
Author for correspondence.
Email: mg-vinokurov@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290
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