Email this article Adsorption of viral particles from the blood plasma of patients with viral hepatitis on nanodiamonds
- Authors: Baron A.V.1,2, Osipov N.V.3, Yashchenko S.V.3, Kokotukha Y.A.3, Baron I.J.4, Puzyr A.P.1, Olkhovskiy I.A.5,6, Bondar V.S.1
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Affiliations:
- Institute of Biophysics, Siberian Branch
- Siberian Federal University
- Krasnoyarsk Regional Center for Prevention and Control of AIDS
- Voino-Yasenetskii State Medical University
- Krasnoyarsk Branch of Hematology Research Center
- Krasnoyarsk Research Center, Siberian Branch
- Issue: Vol 469, No 1 (2016)
- Pages: 244-246
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211375
- DOI: https://doi.org/10.1134/S1607672916040037
- ID: 211375
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Abstract
Adsorption of viral particles from the blood plasma of patients with viral hepatitis B and C on modified nanodiamonds (MNDs) was shown in the in vitro experiments. PCR method showed the treatment of plasma with MNDs leads to a decrease in the viral load by 2–3 orders of magnitude or more in both cases studied. These results make it possible to predict the applicability of MNDs for the development of new technologies of hemodialysis and plasmapheresis for binding and removal of viral particles from the blood of infected patients.
About the authors
A. V. Baron
Institute of Biophysics, Siberian Branch; Siberian Federal University
Author for correspondence.
Email: alexeybaron@mail.ru
Russian Federation, Akademgorodok, Krasnoyarsk, 660036; Svobodnyi pr. 79, Krasnoyarsk, 660041
N. V. Osipov
Krasnoyarsk Regional Center for Prevention and Control of AIDS
Email: alexeybaron@mail.ru
Russian Federation, ul. Karla Marksa 47, Krasnoyarsk, 660049
S. V. Yashchenko
Krasnoyarsk Regional Center for Prevention and Control of AIDS
Email: alexeybaron@mail.ru
Russian Federation, ul. Karla Marksa 47, Krasnoyarsk, 660049
Yu. A. Kokotukha
Krasnoyarsk Regional Center for Prevention and Control of AIDS
Email: alexeybaron@mail.ru
Russian Federation, ul. Karla Marksa 47, Krasnoyarsk, 660049
I. J. Baron
Voino-Yasenetskii State Medical University
Email: alexeybaron@mail.ru
Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, 660022
A. P. Puzyr
Institute of Biophysics, Siberian Branch
Email: alexeybaron@mail.ru
Russian Federation, Akademgorodok, Krasnoyarsk, 660036
I. A. Olkhovskiy
Krasnoyarsk Branch of Hematology Research Center; Krasnoyarsk Research Center, Siberian Branch
Email: alexeybaron@mail.ru
Russian Federation, Krasnoyarsk; Krasnoyarsk, 630036
V. S. Bondar
Institute of Biophysics, Siberian Branch
Email: alexeybaron@mail.ru
Russian Federation, Akademgorodok, Krasnoyarsk, 660036
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