Email this article mRNA expression profile of mouse oligodendrocytes in inflammatory conditions
- Authors: Kuzina E.S.1, Glagoleva I.S.2, Surina E.A.1, Knorre V.D.1, Belogurov A.A.1,2, Tonevitsky A.G.3, Gabibov A.G.1,2,4, Kudriaeva A.A.1, Khaustova N.A.3, Maltseva D.V.3
-
Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University
- BioKlinikum Scientific-Technical Center LLC
- Faculty of Chemistry
- Issue: Vol 469, No 1 (2016)
- Pages: 264-268
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211401
- DOI: https://doi.org/10.1134/S1607672916040086
- ID: 211401
Cite item
Open Access
Access granted
Subscription Access
Abstract
In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the central nervous system in multiple sclerosis as well as the mechanisms of cellular response to benztropine in light of its possible use for the treatment of multiple sclerosis.
About the authors
E. S. Kuzina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: vera.knorre@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
I. S. Glagoleva
Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University
Email: vera.knorre@gmail.com
Russian Federation, ul. Karla Marksa 74, Kazan, Tatarstan, 420055
E. A. Surina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: vera.knorre@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
V. D. Knorre
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: vera.knorre@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
A. A. Belogurov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University
Email: vera.knorre@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; ul. Karla Marksa 74, Kazan, Tatarstan, 420055
A. G. Tonevitsky
BioKlinikum Scientific-Technical Center LLC
Email: vera.knorre@gmail.com
Russian Federation, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088
A. G. Gabibov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Faculty of Chemistry
Email: vera.knorre@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; ul. Karla Marksa 74, Kazan, Tatarstan, 420055; Moscow, 119991
A. A. Kudriaeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: vera.knorre@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
N. A. Khaustova
BioKlinikum Scientific-Technical Center LLC
Email: vera.knorre@gmail.com
Russian Federation, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088
D. V. Maltseva
BioKlinikum Scientific-Technical Center LLC
Email: vera.knorre@gmail.com
Russian Federation, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088
Supplementary files
