Email this article Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells
- Authors: Gudasheva T.A.1, Koliasnikova K.N.1, Antipova T.A.1, Seredenin S.B.1
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Affiliations:
- Zakusov Research Institute of Pharmacology
- Issue: Vol 469, No 1 (2016)
- Pages: 273-276
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211419
- DOI: https://doi.org/10.1134/S1607672916040104
- ID: 211419
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Abstract
It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10–7 and 10–3 M and piracetam at a concentration of 10–3 M increased the content of brainderived neurotrophic factor (BDNF) in the culture of neuronal cells in normal state and under conditions of glutamate and 6-oxydopamine neurotoxicity. This may indicate the possible involvement of BDNF in the mechanism of action of neuropeptide CPG and piracetam.
About the authors
T. A. Gudasheva
Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: tata-sosnovka@mail.ru
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
K. N. Koliasnikova
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
T. A. Antipova
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
S. B. Seredenin
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
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