5-Lipoxygenase inhibitor zileuton inhibits Ca 2+ -responses induced by glutoxim and molixan in macrophages

Z. I. Krutetskaya; L. S. Milenina; A. A. Naumova; V. G. Antonov; A. D. Nozdrachev

doi:10.1134/S1607672916040177

5-Lipoxygenase inhibitor zileuton inhibits Ca²⁺-responses induced by glutoxim and molixan in macrophages

Authors: Krutetskaya Z.I.¹, Milenina L.S.¹, Naumova A.A.¹, Antonov V.G.¹, Nozdrachev A.D.¹
Affiliations:
1. St. Petersburg State University
Issue: Vol 469, No 1 (2016)
Pages: 302-304
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211483
DOI: https://doi.org/10.1134/S1607672916040177
ID: 211483

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Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that 5-lipoxygenase specific inhibitor antiasthmatic agent zileuton significantly inhibits Ca²⁺-responses induced by glutoxim and molixan in macrophages. The results support 5-lipoxygenase involvement in the effect of glutoxim and molixan on intracellular Ca²⁺ concentration in macrophages and indicate the inadvisability of a combined use of drugs glutoxim and molixan and antiasthmatic agent zileuton.