Email this article Synthesis of magnetic silica nanomarkers with controlled physicochemical properties
- Authors: Zelepukin I.V.1,2,3, Nikitin M.P.1,3,4, Cherkasov V.R.3, Nikitin P.I.4, Deyev S.M.1,2, Petrov P.V.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Nizhny Novgorod State University
- Moscow Institute of Physics and Technology (State University)
- Prokhorov Institute of General Physics
- Issue: Vol 470, No 1 (2016)
- Pages: 335-337
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211555
- DOI: https://doi.org/10.1134/S1607672916050100
- ID: 211555
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Abstract
Magnetic markers which can be detected with an extremely high sensitivity with the method of magnetic particle quantification (MPQ) were synthesized. Using a controlled Stober reaction, a set of magnetic silica markers of different sizes and zeta potentials was obtained. The use of a carboxymethyl dextran polymer to stabilize the magnetite particles during the synthesis made it possible to substantially reduce the detection limit of the obtained construct, which opens up new opportunities for creating effective diagnostic nanoagents.
About the authors
I. V. Zelepukin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Nizhny Novgorod State University; Moscow Institute of Physics and Technology (State University)
Author for correspondence.
Email: zelepukin@phystech.edu
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; pr. Gagarina 23, Nizhny Novgorod, 630600; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
M. P. Nikitin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Moscow Institute of Physics and Technology (State University); Prokhorov Institute of General Physics
Email: zelepukin@phystech.edu
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700; ul. Vavilova 38, Moscow, 119991
V. R. Cherkasov
Moscow Institute of Physics and Technology (State University)
Email: zelepukin@phystech.edu
Russian Federation, Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
P. I. Nikitin
Prokhorov Institute of General Physics
Email: zelepukin@phystech.edu
Russian Federation, ul. Vavilova 38, Moscow, 119991
S. M. Deyev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Nizhny Novgorod State University
Email: zelepukin@phystech.edu
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; pr. Gagarina 23, Nizhny Novgorod, 630600
P. V. Petrov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: zelepukin@phystech.edu
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
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