Antitumor efficacy of combined gene and radiotherapy in animals


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Abstract

Antitumor efficacy of the combined suicide gene therapy and radiotherapy was studied on the model of CT26 murine colon adenocarcinoma. CMV-FCU1-IRES-mGM-CSF-pGL3 construct with PEG-PEI-TAT (FCU1–mGM/5-FC) block copolymer as a vector was used for intratumoral administration. Tumors were irradiated with a single 5 Gy dose. The efficacy was evaluated according to the grade of tumor growth inhibition (T/C) and lifespan of the animals. Pronounced antitumor activity of the combined use of FCU1–mGM/5-FC system with radiotherapy on the background of prolonged lifespan and the synergism of the applied methods was revealed.

About the authors

O. A. Bezborodova

National Medical Research Radiological Center (NMRRC)

Author for correspondence.
Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

E. R. Nemtsova

National Medical Research Radiological Center (NMRRC)

Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

A. R. Gevorkov

National Medical Research Radiological Center (NMRRC)

Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

A. V. Boyko

National Medical Research Radiological Center (NMRRC)

Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

J. B. Venediktova

National Medical Research Radiological Center (NMRRC)

Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

I. V. Alekseenko

Institute of Molecular Genetics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Russian Federation, pl. Akademika Kurchatova 46, Moscow, 123182; ul. Miklukho-Maklaya 16/10, Moscow, 117997

M. B. Kostina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997

G. S. Monastyrskaya

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997

E. D. Sverdlov

Institute of Molecular Genetics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: olgabezborodova@yandex.ru
Russian Federation, pl. Akademika Kurchatova 46, Moscow, 123182; ul. Miklukho-Maklaya 16/10, Moscow, 117997

E. V. Khmelevskiy

National Medical Research Radiological Center (NMRRC)

Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

R. I. Yakubovskaya

National Medical Research Radiological Center (NMRRC)

Email: olgabezborodova@yandex.ru
Russian Federation, Obninsk, Kaluga oblast

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