Email this article The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells
- Authors: Zamorina S.A.1, Litvinova L.S.2, Yurova K.A.2, Dunets N.A.2, Khaziakhmatova O.G.2, Timganova V.P.1, Bochkova M.S.1, Khramtsov P.V.1, Rayev M.B.1,3
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Kant Baltic Federal University
- Yeltsin Ural Federal University
- Issue: Vol 470, No 1 (2016)
- Pages: 361-363
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211613
- DOI: https://doi.org/10.1134/S1607672916050161
- ID: 211613
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Abstract
The role of human pregnancy-specific β1-glycoprotein (PSG) in the regulation of expression of the transcription factor FOXP3 was studied. It is found that, under conditions of directed induction of phenotypic changes in CD4+ lymphocytes to regulatory T cells (Treg), PSG at high concentrations (10 and 100 μg/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that PSG (1 and 100 μg/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4+ lymphocytes. Thus, PSG stimulates FOXP3 expression in immunocompetent cells.
About the authors
S. A. Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: mraev@iegm.ru
Russian Federation, ul. Goleva 13, Perm, 614081
L. S. Litvinova
Kant Baltic Federal University
Email: mraev@iegm.ru
Russian Federation, ul. Botkina 3, Kaliningrad
K. A. Yurova
Kant Baltic Federal University
Email: mraev@iegm.ru
Russian Federation, ul. Botkina 3, Kaliningrad
N. A. Dunets
Kant Baltic Federal University
Email: mraev@iegm.ru
Russian Federation, ul. Botkina 3, Kaliningrad
O. G. Khaziakhmatova
Kant Baltic Federal University
Email: mraev@iegm.ru
Russian Federation, ul. Botkina 3, Kaliningrad
V. P. Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: mraev@iegm.ru
Russian Federation, ul. Goleva 13, Perm, 614081
M. S. Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: mraev@iegm.ru
Russian Federation, ul. Goleva 13, Perm, 614081
P. V. Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: mraev@iegm.ru
Russian Federation, ul. Goleva 13, Perm, 614081
M. B. Rayev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Yeltsin Ural Federal University
Author for correspondence.
Email: mraev@iegm.ru
Russian Federation, ul. Goleva 13, Perm, 614081; Yekaterinburg
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