Molecular mechanisms of synthesis of noradrenaline as an inducer of development in the adrenal glands of rats in ontogenesis


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Abstract

The level of gene expression and the protein content of tyrosine hydroxylase and dopamine β-hydroxylase were determined. In the perinatal period of rats, when noradrenaline functions as a morphogenetic factor, the level of gene expression of these enzymes increased and the content of protein products of these genes was almost unchanged, indicating the difference in the regulatory mechanisms of their transcription and translation.

About the authors

N. S. Bondarenko

Koltzov Institute of Developmental Biology

Author for correspondence.
Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334

A. R. Murtazina

Koltzov Institute of Developmental Biology

Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334

Yu. O. Nikishina

Koltzov Institute of Developmental Biology

Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334

A. Ya. Sapronova

Koltzov Institute of Developmental Biology

Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334

M. V. Ugrumov

Koltzov Institute of Developmental Biology; National Research University Higher School of Economics

Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334; Moscow, 101000

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