Molecular mechanisms of synthesis of noradrenaline as an inducer of development in the adrenal glands of rats in ontogenesis
- Authors: Bondarenko N.S.1, Murtazina A.R.1, Nikishina Y.O.1, Sapronova A.Y.1, Ugrumov M.V.1,2
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Affiliations:
- Koltzov Institute of Developmental Biology
- National Research University Higher School of Economics
- Issue: Vol 472, No 1 (2017)
- Pages: 23-26
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211804
- DOI: https://doi.org/10.1134/S1607672917010070
- ID: 211804
Cite item
Abstract
The level of gene expression and the protein content of tyrosine hydroxylase and dopamine β-hydroxylase were determined. In the perinatal period of rats, when noradrenaline functions as a morphogenetic factor, the level of gene expression of these enzymes increased and the content of protein products of these genes was almost unchanged, indicating the difference in the regulatory mechanisms of their transcription and translation.
About the authors
N. S. Bondarenko
Koltzov Institute of Developmental Biology
Author for correspondence.
Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334
A. R. Murtazina
Koltzov Institute of Developmental Biology
Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334
Yu. O. Nikishina
Koltzov Institute of Developmental Biology
Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334
A. Ya. Sapronova
Koltzov Institute of Developmental Biology
Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334
M. V. Ugrumov
Koltzov Institute of Developmental Biology; National Research University Higher School of Economics
Email: n.bondarenko@idbras.ru
Russian Federation, Moscow, 119334; Moscow, 101000
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