Alzheimer’s disease Aβ 42  peptide induces an increase in Na,K-ATPase glutathionylation

V. A. Lakunina; I. Y. Petrushanko; K. M. Burnysheva; V. A. Mitkevich; A. A. Makarov

doi:10.1134/S1607672917020077

Alzheimer’s disease Aβ₄₂ peptide induces an increase in Na,K-ATPase glutathionylation

Authors: Lakunina V.A.¹, Petrushanko I.Y.¹, Burnysheva K.M.¹, Mitkevich V.A.¹, Makarov A.A.¹
Affiliations:
1. Engelhardt Institute of Molecular Biology
Issue: Vol 473, No 1 (2017)
Pages: 114-117
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211861
DOI: https://doi.org/10.1134/S1607672917020077
ID: 211861

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Abstract

We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Aβ₄₂), an Alzheimer’s disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation α-subunit of Na,K-ATPase. To restore the activity of Na,K-ATPase, it is proposed to use reducing agents, which promote normalization of the redox status of cells and deglutathionylation of the protein.