N -acyl dopamines induce apoptosis in PC12 cell line via the GPR55 receptor activation

M. G. Akimov; A. M. Ashba; N. M. Gretskaya; V. V. Bezuglov

doi:10.1134/S1607672917030012

N-acyl dopamines induce apoptosis in PC12 cell line via the GPR55 receptor activation

Authors: Akimov M.G.¹, Ashba A.M.¹, Gretskaya N.M.¹, Bezuglov V.V.¹
Affiliations:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Issue: Vol 474, No 1 (2017)
Pages: 155-158
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211886
DOI: https://doi.org/10.1134/S1607672917030012
ID: 211886

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Abstract

Dopamine amides of arachidonic, docosahexaenoic, and oleic acids were found to induce apoptosis in PC12 cells, which was blocked exclusively by antagonists and preincubation agonists of the receptor GPR55, belonging to the group of non-CB1/CB2 receptors.