MicroRNA in hormonal mechanisms of regulation of NK cell function

S. V. Shirshev; I. V. Nekrasova; O. L. Gorbunova; E. G. Orlova; I. L. Maslennikova

doi:10.1134/S160767291703005X

MicroRNA in hormonal mechanisms of regulation of NK cell function

Authors: Shirshev S.V.¹, Nekrasova I.V.¹, Gorbunova O.L.¹, Orlova E.G.¹, Maslennikova I.L.¹
Affiliations:
1. Institute of Ecology and Genetics of Microorganisms, Ural Department
Issue: Vol 474, No 1 (2017)
Pages: 168-172
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211892
DOI: https://doi.org/10.1134/S160767291703005X
ID: 211892

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Abstract

We investigated the effect of human chorionic gonadotropin, estriol, leptin, ghrelin, and kisspeptin on the microRNA expression in separated NK cells. All of these hormones are able to effectively modulate the expression of microRNAs both stimulating and suppressing the cytotoxic potential of NK cells and thereby indirectly regulate the functions of these lymphocytes.