Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad  Bufo bufo —New agonists of ionotropic γ-aminobutyric acid receptors

D. S. Lebedev; I. A. Ivanov; E. V. Kryukova; V. G. Starkov; V. I. Tsetlin; Yu. N. Utkin

doi:10.1134/S1607672917030127

Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo—New agonists of ionotropic γ-aminobutyric acid receptors

Authors: Lebedev D.S.¹, Ivanov I.A.¹, Kryukova E.V.¹, Starkov V.G.¹, Tsetlin V.I.¹, Utkin Y.N.¹^,2
Affiliations:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
2. The National University of Science and Technology MISiS
Issue: Vol 474, No 1 (2017)
Pages: 178-182
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211894
DOI: https://doi.org/10.1134/S1607672917030127
ID: 211894

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Abstract

Compounds activating γ-aminobutyric acid type A receptor were isolated from the toad Bufo bufo venom as a result of chromatographic separation. Analysis of the structure of these compounds by mass spectrometry and nuclear magnetic resonance showed that they are arginine derivatives of dicarboxylic acids and represent suberylarginine, pimeloylarginine, and adipoylarginine.