Email this article New paradoxical three-finger toxin from the cobra Naja kaouthia venom: Isolation and characterization
- Authors: Osipov A.V.1, Meshcheryakova A.V.1,2, Starkov V.G.1, Ziganshin R.K.1, Oustitch T.L.3, Peters L.3, Tsetlin V.I.1, Utkin Y.N.1,4
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Department of Biomolecular Sciences
- Envirologix Inc.
- The National University of Science and Technology MISiS
- Issue: Vol 475, No 1 (2017)
- Pages: 264-266
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211945
- DOI: https://doi.org/10.1134/S1607672917040068
- ID: 211945
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Abstract
A new three-finger toxin nakoroxin was isolated from the cobra Naja kaouthia venom, and its complete amino acid sequence was established. Nakoroxin belongs to the group of “orphan” toxins, data on the biological activity of which are practically absent. Nakoroxin shows no cytotoxicity and does not inhibit the binding of α-bungarotoxin to nicotinic acetylcholine receptors of muscle and α7 types. However, it potentiates the binding of α-bungarotoxin to the acetylcholine-binding protein from Lymnaea stagnalis. This is the first toxin with such an unusual property.
About the authors
A. V. Osipov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Russian Federation, Moscow, 117997
A. V. Meshcheryakova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Department of Biomolecular Sciences
Email: utkin@mx.ibch.ru
Russian Federation, Moscow, 117997; Rehovot
V. G. Starkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Russian Federation, Moscow, 117997
R. Kh. Ziganshin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Russian Federation, Moscow, 117997
T. L. Oustitch
Envirologix Inc.
Email: utkin@mx.ibch.ru
United States, Portland
L.-E. Peters
Envirologix Inc.
Email: utkin@mx.ibch.ru
United States, Portland
V. I. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Russian Federation, Moscow, 117997
Yu. N. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; The National University of Science and Technology MISiS
Author for correspondence.
Email: utkin@mx.ibch.ru
Russian Federation, Moscow, 117997; Moscow, 119049
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