Email this article The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma
- Authors: Inzhevatkin E.V.1, Savchenko A.A.2
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Affiliations:
- Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS
- Research Institute for Medical Problems in the North Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”
- Issue: Vol 475, No 1 (2017)
- Pages: 277-279
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211953
- DOI: https://doi.org/10.1134/S1607672917040081
- ID: 211953
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Abstract
In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.
About the authors
E. V. Inzhevatkin
Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS
Author for correspondence.
Email: inscience@mail.ru
Russian Federation, Akademgorodok 50, Krasnoyarsk, 660036
A. A. Savchenko
Research Institute for Medical Problems in the North Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”
Email: inscience@mail.ru
Russian Federation, ul. Partizana Zheleznyaka 3 G, Krasnoyarsk, 660022
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