Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development

E. V. Chernigovskaya; O. O. Lebedenko; A. V. Nidenfyur; L. S. Nikitina; M. V. Glazova

doi:10.1134/S1607672917050015

Analysis of ERK1/2 kinases in the inferior colliculus of rats genetically prone to audiogenic seizures during postnatal development

Authors: Chernigovskaya E.V.¹, Lebedenko O.O.¹, Nidenfyur A.V.¹, Nikitina L.S.¹, Glazova M.V.¹
Affiliations:
1. Sechenov Institute of Evolutionary Physiology and Biochemistry
Issue: Vol 476, No 1 (2017)
Pages: 296-298
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/211966
DOI: https://doi.org/10.1134/S1607672917050015
ID: 211966

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Abstract

The activity of ERK1/2 kinases in the quadrigemina inferior colliculus of Krushinsky–Molodkina rats of different age, which are characterized by an increased seizure readiness compared to Wistar rats, was analyzed. An increased (probably genetically determined) activity of these enzymes during the development of epileptiform activity in ontogeny was found, which may be the cause of abnormalities in the neurotransmitter system functioning.