Email this article Quantitative target proteomics of chromosome 13 human blood plasma proteins
- Authors: Kopylov A.T.1, Ilgisonis E.V.1, Tikhonova O.V.1, Farafonova T.E.1, Novikova S.E.1, Zgoda V.G.1, Ponomarenko E.A.1, Lisitsa A.V.1, Markin A.A.2, Morukov B.V.2, Grigoriev A.I.2, Archakov A.I.1
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Affiliations:
- Orekhovich Institute of Biomedical Chemistry
- Institute of Biomedical Problems
- Issue: Vol 476, No 1 (2017)
- Pages: 326-328
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211985
- DOI: https://doi.org/10.1134/S160767291705009X
- ID: 211985
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Abstract
Quantitative proteomic analysis of 50 blood plasma samples of healthy volunteers who underwent a comprehensive medical examination and were found eligible for space flights was performed. As a result of directed mass spectrometric analysis, signals for 128 proteins, which accounted for nearly 40% of the total number of chromosome 13 gene products, were detected. The analysis of interindividual variation of concentrations of chromosome 13 proteins showed the presence of a pool comprising 41 proteins with a low variation (CV < 30%), which can potentially be used as biomarkers.
About the authors
A. T. Kopylov
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
E. V. Ilgisonis
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
O. V. Tikhonova
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
T. E. Farafonova
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
S. E. Novikova
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
V. G. Zgoda
Orekhovich Institute of Biomedical Chemistry
Author for correspondence.
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
E. A. Ponomarenko
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
A. V. Lisitsa
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
A. A. Markin
Institute of Biomedical Problems
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 123007
B. V. Morukov
Institute of Biomedical Problems
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 123007
A. I. Grigoriev
Institute of Biomedical Problems
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 123007
A. I. Archakov
Orekhovich Institute of Biomedical Chemistry
Email: vic@ibmh.msk.su
Russian Federation, Moscow, 119121
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