Osteogenic differentiation of mouse bone marrow stromal cells on fibroin microcarriers

A. V. Goncharenko; M. S. Kotlyarova; A. M. Moisenovich; A. Y. Arkhipova; D. A. Kulikov; A. S. Konkov; A. V. Kulikov; A. E. Mashkov; I. I. Agapov; M. M. Moisenovich; M. P. Kirpichnikov

doi:10.1134/S1607672917060011

Osteogenic differentiation of mouse bone marrow stromal cells on fibroin microcarriers

Authors: Goncharenko A.V.¹, Kotlyarova M.S.¹, Moisenovich A.M.¹, Arkhipova A.Y.¹, Kulikov D.A.², Konkov A.S.¹, Kulikov A.V.³, Mashkov A.E.², Agapov I.I.⁴, Moisenovich M.M.¹, Kirpichnikov M.P.¹
Affiliations:
1. Biological Faculty
2. Vladimirskii Moscow Regional Research Clinical Institute
3. Institute of Theoretical and Experimental Biophysics, Pushchino Branch
4. Shumakov Research Institute of Transplantation and Artificial Organs
Issue: Vol 477, No 1 (2017)
Pages: 345-348
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/212003
DOI: https://doi.org/10.1134/S1607672917060011
ID: 212003

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Abstract

We investigated the proliferation and osteogenic differentiation of mesenchymal stem cells cultured on fibroin microcarriers. Effective cell proliferation on the surface of the microcarriers, determined by the large surface area, and the contribution of microcarrier mineralization to the stimulation of the osteogenic differentiation of mesenchymal stem cells was revealed.