Email this article Expression of focal adhesion genes in mesenchymal stem cells under simulated microgravity
- Authors: Ratushnyy A.Y.1, Buravkova L.B.1
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Affiliations:
- Institute for Biomedical Problems
- Issue: Vol 477, No 1 (2017)
- Pages: 354-356
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212007
- DOI: https://doi.org/10.1134/S1607672917060035
- ID: 212007
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Abstract
The expression of 84 focal adhesion genes of multipotent mesenchymal stromal cells (MMSCs) after 96-h microgravity simulation at 3D clinorotation was studied. The upregulation of ITGA6, ITGA7, BCAR1, GRB2, CAV1, and DIAPH1 and the downregulation of ITGA11, ITGAV, ITGB1, PTEN, PTK2 (FAK), ARHGAP5, DOCK1, ROCK2, and AKT3 was found. These changes at the transcriptional level may be a cause of the reduction of the osteogenic potential of MMSCs and their ability to migration and adhesion in microgravity.
About the authors
A. Yu. Ratushnyy
Institute for Biomedical Problems
Email: buravkova@imbp.ru
Russian Federation, Khoroshevskoe sh. 76a, Moscow, 123007
L. B. Buravkova
Institute for Biomedical Problems
Author for correspondence.
Email: buravkova@imbp.ru
Russian Federation, Khoroshevskoe sh. 76a, Moscow, 123007
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