Email this article Cross-reactivity of antigens and antibodies belonging to different pathogenic types of human papillomaviruses
- Authors: Salyaev R.K.1, Rekoslavskaya N.I.1,2, Stolbikov A.S.1,3
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Affiliations:
- Siberian Institute of Physiology and Biochemistry, Siberian Branch
- Irkutsk Scientific Center, Siberian Branch
- Irkutsk State University
- Issue: Vol 477, No 1 (2017)
- Pages: 372-376
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212023
- DOI: https://doi.org/10.1134/S1607672917060084
- ID: 212023
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Abstract
The analysis of the properties of a quadrivalent peroral vaccine against the cervical cancer, which was created in a plant expression system on the base of transgenic tomato fruits, by immunoassay and Western blot hybridization showed that the antibodies against human papilloma virus 16 L1 (HPV16 L1) actively interacted not only with the antigenic proteins HPV18 L1, HPV31 L1, and HPV45 L1, but also with the antigenic protein HPV6 L1, which belongs to another HPV family. Thus, new data on the possibility of crossreactivity between antibodies and antigens belonging to remote HPV families were obtained.
About the authors
R. K. Salyaev
Siberian Institute of Physiology and Biochemistry, Siberian Branch
Author for correspondence.
Email: salyaev@sifibr.irk.ru
Russian Federation, Irkutsk
N. I. Rekoslavskaya
Siberian Institute of Physiology and Biochemistry, Siberian Branch; Irkutsk Scientific Center, Siberian Branch
Email: salyaev@sifibr.irk.ru
Russian Federation, Irkutsk; Irkutsk
A. S. Stolbikov
Siberian Institute of Physiology and Biochemistry, Siberian Branch; Irkutsk State University
Email: salyaev@sifibr.irk.ru
Russian Federation, Irkutsk; Irkutsk
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