Phospholipase A 2  Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca 2+  Concentration in Macrophages

Z. I. Krutetskaya; L. S. Milenina; A. A. Naumova; S. N. Butov; V. G. Antonov; A. D. Nozdrachev

doi:10.1134/S1607672918010118

Phospholipase A₂ Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca²⁺ Concentration in Macrophages

Authors: Krutetskaya Z.I.¹, Milenina L.S.¹, Naumova A.A.¹, Butov S.N.¹, Antonov V.G.¹, Nozdrachev A.D.¹
Affiliations:
1. St. Petersburg State University
Issue: Vol 478, No 1 (2018)
Pages: 41-43
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/212103
DOI: https://doi.org/10.1134/S1607672918010118
ID: 212103

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Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that phospholipase A₂ inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednisolone and dexamethasone attenuate Ca²⁺ responses induced by neuroleptic trifluoperazine in macrophages. The results suggest the involvement of phospholipase A₂ and arachidonic acid metabolism cascade in the effect of trifluoperazine on intracellular Ca²⁺ concentration in macrophages.