Email this article A Universal Tumor-Specific Promoter for Cancer Gene Therapy
- Authors: Alekseenko I.V.1,2, Pleshkan V.V.1,2, Sass A.V.1, Filyukova O.B.1, Snezhkov E.V.1, Sverdlov E.D.1,2
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Molecular Genetics
- Issue: Vol 480, No 1 (2018)
- Pages: 158-161
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212296
- DOI: https://doi.org/10.1134/S1607672918030092
- ID: 212296
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Abstract
An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters was constructed. Studies in in vitro and ex vivo therapeutic systems showed that the designed promoter exhibits a high activity in tumor cells, which is comparable to the activity of the CMV constitutive promoter.
About the authors
I. V. Alekseenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics
Author for correspondence.
Email: irina.alekseenko@mail.ru
Russian Federation, Moscow, 117997; Moscow, 123182
V. V. Pleshkan
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics
Email: irina.alekseenko@mail.ru
Russian Federation, Moscow, 117997; Moscow, 123182
A. V. Sass
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Russian Federation, Moscow, 117997
O. B. Filyukova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Russian Federation, Moscow, 117997
E. V. Snezhkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: irina.alekseenko@mail.ru
Russian Federation, Moscow, 117997
E. D. Sverdlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Institute of Molecular Genetics
Email: irina.alekseenko@mail.ru
Russian Federation, Moscow, 117997; Moscow, 123182
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