Email this article Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?
- Authors: Petrova I.O.1, Tyganov S.A.1, Mirzoev T.M.1, Tsaturyan A.K.2, Kozlovskaya I.B.1, Shenkman B.S.1
-
Affiliations:
- Institute of Biomedical Problems
- Institute of Mechanics
- Issue: Vol 481, No 1 (2018)
- Pages: 205-207
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212363
- DOI: https://doi.org/10.1134/S1607672918040075
- ID: 212363
Cite item
Open Access
Access granted
Subscription Access
Abstract
The study was aimed at testing the hypotheses about the role of cross-bridges and calpains in reduction of rat soleus passive tension under conditions of hindlimb unloading. For this purpose, we used an inhibitor of μ-calpain PD 150606 as well as a blocker of actomyosin interaction (blebbistatin). It was found for the first time that a decrease in passive tension of rat soleus after 3-day hindlimb unloading is associated with the activity of μ-calpain and does not depend on the processes of cross-bridges formation.
About the authors
I. O. Petrova
Institute of Biomedical Problems
Email: bshenkman@mail.ru
Russian Federation, Moscow, 123007
S. A. Tyganov
Institute of Biomedical Problems
Email: bshenkman@mail.ru
Russian Federation, Moscow, 123007
T. M. Mirzoev
Institute of Biomedical Problems
Email: bshenkman@mail.ru
Russian Federation, Moscow, 123007
A. K. Tsaturyan
Institute of Mechanics
Email: bshenkman@mail.ru
Russian Federation, Moscow, 119192
I. B. Kozlovskaya
Institute of Biomedical Problems
Email: bshenkman@mail.ru
Russian Federation, Moscow, 123007
B. S. Shenkman
Institute of Biomedical Problems
Author for correspondence.
Email: bshenkman@mail.ru
Russian Federation, Moscow, 123007
Supplementary files
