Email this article Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells
- Authors: Gnatenko D.A.1, Kopantzev E.P.1, Sverdlov E.D.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 481, No 1 (2018)
- Pages: 217-218
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212381
- DOI: https://doi.org/10.1134/S1607672918040105
- ID: 212381
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Abstract
Stimulation of BxPC-3, Panc-1, and MIA PaCA-2 pancreatic cancer cells with EGF, HGF, FGF-1, FGF-2, FGF-7, and FGF-10 growth factors caused changes in the expression of master genes regulating pancreatic development (SOX9, HNF3b, GATA-4, GATA-6, and HES1). This, in turn, caused changes in the expression profile of important transcription factors, embryonic development regulators. It was also found that the master genes belonging to the same family may cause opposite effects (suppression or enhancement of expression of a particular transcriptional regulator) in the same cell line.
About the authors
D. A. Gnatenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: gnatenkodmitrij@gmail.com
Russian Federation, Moscow, 117997
E. P. Kopantzev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: gnatenkodmitrij@gmail.com
Russian Federation, Moscow, 117997
E. D. Sverdlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: gnatenkodmitrij@gmail.com
Russian Federation, Moscow, 117997
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