Correlation between Expression of  KLF5  and  ZEB1  Transcription Factor Genes in Pancreatic Cancer

M. V. Zinovyeva; L. G. Nikolaev; L. G. Kondratyeva; T. V. Vinogradova; E. D. Sverdlov

doi:10.1134/S1607672918040129

Correlation between Expression of KLF5 and ZEB1 Transcription Factor Genes in Pancreatic Cancer

Authors: Zinovyeva M.V.¹, Nikolaev L.G.¹, Kondratyeva L.G.¹, Vinogradova T.V.¹, Sverdlov E.D.¹
Affiliations:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Issue: Vol 481, No 1 (2018)
Pages: 219-221
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/212387
DOI: https://doi.org/10.1134/S1607672918040129
ID: 212387

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Abstract

The mRNA content of the transcription factors KLF5 and ZEB1 was studied in pancreatic tumor tissues and in fetal and normal pancreas. Transcription of these factors was not high and similar in normal and fetal pancreatic tissues but greatly increased in the pancreatic ductal adenocarcinoma tissues. A significant positive correlation between the KLF5 and ZEB1 transcription levels in the pancreatic tumor tissues was observed.