Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity
- Authors: Gudasheva T.A.1, Konstantinopolsky M.A.1, Tarasiuk A.V.1, Kolik L.G.1, Seredenin S.B.1
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Affiliations:
- Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 485, No 1 (2019)
- Pages: 123-125
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212908
- DOI: https://doi.org/10.1134/S1607672919020121
- ID: 212908
Cite item
Abstract
Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.
About the authors
T. A. Gudasheva
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Author for correspondence.
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315
M. A. Konstantinopolsky
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315
A. V. Tarasiuk
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315
L. G. Kolik
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315
S. B. Seredenin
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315
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