Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity


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Abstract

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.

About the authors

T. A. Gudasheva

Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences

Author for correspondence.
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315

M. A. Konstantinopolsky

Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences

Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315

A. V. Tarasiuk

Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences

Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315

L. G. Kolik

Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences

Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315

S. B. Seredenin

Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences

Email: tata-sosnovka@mail.ru
Russian Federation, Moscow, 125315

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