Email this article The Generation of the Human mAb RabD4 Specific to the Rabies Virus Glycoprotein and Characterization Thereof
- Authors: Ilina E.N.1, Solopova E.V.2, Aliev T.K.1, Larina M.V.3, Balabashin D.S.3, Varlamov N.E.2, Dolgikh D.A.1,3, Sveshnikov P.G.2, Kirpichnikov M.P.1,3
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Affiliations:
- Moscow State University
- All-Russia Research Center of Molecular Diagnostics and Therapy
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 485, No 1 (2019)
- Pages: 126-128
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212914
- DOI: https://doi.org/10.1134/S1607672919020133
- ID: 212914
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Abstract
We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation of human peripheral B cells produced by immunized donor. The human mAb RabD4 showed a high antigen-binding activity and virus-neutralizing activity in the FAVN test with the CVS-11 rabies virus.
About the authors
E. N. Ilina
Moscow State University
Author for correspondence.
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991
E. V. Solopova
All-Russia Research Center of Molecular Diagnosticsand Therapy
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 117149
T. K. Aliev
Moscow State University
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991
M. V. Larina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 117997
D. S. Balabashin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 117997
N. E. Varlamov
All-Russia Research Center of Molecular Diagnosticsand Therapy
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 117149
D. A. Dolgikh
Moscow State University; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997
P. G. Sveshnikov
All-Russia Research Center of Molecular Diagnosticsand Therapy
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 117149
M. P. Kirpichnikov
Moscow State University; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Ekaterina.iljina.7@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997
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