Email this article Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins
- Authors: Lankin V.Z.1, Sharapov M.G.2, Goncharov R.G.2, Tikhaze A.K.1, Novoselov V.I.2
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Affiliations:
- National Medical Research Center of Cardiology, Ministry of Healthcare of the Russian Federation
- Institute of Cell Biophysics, Russian Academy of Sciences
- Issue: Vol 485, No 1 (2019)
- Pages: 132-134
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212926
- DOI: https://doi.org/10.1134/S1607672919020157
- ID: 212926
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Abstract
It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.
About the authors
V. Z. Lankin
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Author for correspondence.
Email: lankin941@mail.ru
Russian Federation, Moscow,
121552
M. G. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Russian Federation, Pushchino, Moscow oblast, 142290
R. G. Goncharov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Russian Federation, Pushchino, Moscow oblast, 142290
A. K. Tikhaze
National Medical Research Center of Cardiology, Ministryof Healthcare of the Russian Federation
Email: lankin941@mail.ru
Russian Federation, Moscow,
121552
V. I. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: lankin941@mail.ru
Russian Federation, Pushchino, Moscow oblast, 142290
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